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KMID : 0371619870030010089
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 1 p.89 ~ p.95
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The effect of WK-101 on the human lymphocyte chromosome in vitro
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鄭然泰/Chung, Yeun Tai
朴承澤/金丁中/韓斗錫/金在百/Park, Seung Taeck/Kim, Jeong Joong/, Du Seok Han/Kim, Jae Baek
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Abstract
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In order to investigate the effect of WK-101 on the human chromosomes, the frequency of sister chromatid exchange were examined after cultured human peripheral lymphocyte exposed to WK-101 and acetaldehyde.
The results obtained were as followings ;
1. The acetaldehyde treated groups showed does-dependent increase of the frequency of sister chromatid exchange.
2. The WK-101 treated groups showed similar frequency of sister chromatid exchange as compared with the control group.
3. The WK-101 and the acetaldehyde treated groups showed markedly increase of the frequency of sister chromatid exchange.
In these cases. Increase of the frequency of sister chromatid exchange might be due to cytotoxicity by acetaldehyde.
From the above results. It is suggested that WK-101 did not show the remarkable effect for the exchange of sister chromatid.
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KEYWORD
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